That year, neuroscientist Matthew Schrag discovered doctored images in this and many of Lesné’s other papers, including others purporting to provide evidence for the amyloid hypothesis. These images had been manually edited and cropped together to falsely show support for the papers’ hypotheses. Notably, these frauds all made it through the formalized “peer review” processes of Nature and six other academic journals undetected, before eventually being uncovered by unrelated channels.
Schrag’s investigation that uncovered the fraudulent papers began as a tangent from his work uncovering doctored images used in studies supporting simufilam, an experimental drug for Alzheimer’s disease. The suspicion would prove vindicated when in June 2024 Hoau-Yan Wang, a paid adviser to simufilam’s developer, was indicted by a federal grand juryfor fabricating data and images in simufilam studies for which he obtained $16 million in National Institutes of Health (NIH) grants, following a 2021 petition to the Food and Drug Administration, a method of reporting research fraud which is highly unusual if not unique.
Follow-up to evidence of Lesné’s fraud was slow. Schrag’s discovery kicked off two years of wrangling, eventually leading all of Lesné’s coauthors—but not Lesné himself—to agree to retract the 2006 Nature paper. As Sciencereported in 2022, “The Nature paper has been cited in about 2300 scholarly articles—more than all but four other Alzheimer’s basic research reports published since 2006, according to the Web of Science database. Since then, annual NIH support for studies labeled ‘amyloid, oligomer, and Alzheimer’s’ has risen from near zero to $287 million in 2021. Lesné and [his coauthor] Ashe helped spark that explosion, experts say.”
Scientists must now untangle the strands of fraud woven through decades of arguments stretching across a billion dollars worth of research. The paper’s contribution to the allocation of this billion dollars might also be a reason why such a widely-cited paper, presumably read by thousands of experts where some must have spotted the fraud, wasn’t reported earlier. Whether the amyloid hypothesis survives or not, this fraud has likely delayed the arrival of life-saving medication for tens of millions of people, perhaps by many years. If so, it is a humanitarian disaster larger than most wars.