By Mandy McLaren, Ryan Huddle and Neena Hagen

Question 2 supporters, including the influential Massachusetts Teachers Association, had argued the MCAS graduation requirement unfairly penalized students with disabilities and those still learning English. About 700 students, primarily from those two groups, fail annually to earn a diploma because of their MCAS scores, according to state data.

Opponents, meanwhile, said the requirement, which first applied to the class of 2003, raised the bar for education in the Commonwealth by setting a common standard for all students to meet. Business leaders largely opposed Question 2, pointing to research showing the correlation of strong MCAS scores and future earnings in the labor market.

Supporters of Question 2 trounced opponents particularly in western Massachusetts, with several towns west of the Quabbin Reservoir, including Shutesbury, Northampton, Wendell, Easthampton, and Montague, posting the night’s largest victory margins, with roughly 3 in 4 voters there casting ballots in support of the measure. Question 2 also saw strong support in Holyoke, a district whose students were disproportionately affected by the graduation requirement, with 73 percent voting in favor of ending the high-stakes mandate.